Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

David Brea; Tomás Sobrino; Manuel Rodríguez-Yáñez; Pedro Ramos-Cabrer; Jesús Agulla; Raquel Rodríguez-González; Francisco Campos; Miguel Blanco; José Castillo

doi:10.1016/j.clim.2011.02.001

Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

Clin Immunol. 2011 May;139(2):193-8. doi: 10.1016/j.clim.2011.02.001. Epub 2011 Feb 26.

Authors

David Brea¹, Tomás Sobrino, Manuel Rodríguez-Yáñez, Pedro Ramos-Cabrer, Jesús Agulla, Raquel Rodríguez-González, Francisco Campos, Miguel Blanco, José Castillo

Affiliation

¹ Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.

PMID: 21354862
DOI: 10.1016/j.clim.2011.02.001

Abstract

Toll-like receptors are innate immunity receptors that activate inflammation and adaptive immunity. Our objectives were to analyze the association between TLR3, 7, 8 and 9 expressions and clinical outcome in patients with ischemic stroke and the expression of inflammatory molecules. One hundred-ten patients with ischemic stroke were included within 12h of symptoms onset. Stroke severity was evaluated by the NIHSS, and functional outcome was assessed at 3 months by the modified Rankin Scale. Infarct volume at 4-7 days was measured on Computed Tomography imaging. TLR7 and TLR8 at different time points were independently associated with poor outcome. TLR8 was also correlated with infarct volumes. Furthermore, TLR7 and TLR8 on admission were correlated with levels of IL6 and IL1β at 24h, 72 h and 7 days. In conclusion, TLR 7 and TLR8 expressions are associated with poor outcome and greater inflammatory response in acute ischemic stroke.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Atrial Fibrillation / physiopathology
Blood Glucose / metabolism
Brain Infarction / etiology
Brain Infarction / pathology
Brain Ischemia / complications*
C-Reactive Protein / metabolism
Cell Adhesion Molecules / blood
Female
Gene Expression / genetics
Gene Expression / immunology
Humans
Inflammation / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Leukocytes, Mononuclear / metabolism
Male
Matrix Metalloproteinase 9 / blood
Middle Aged
Prognosis
Stroke / diagnosis*
Stroke / etiology
Stroke / metabolism*
Stroke / pathology
Stroke / physiopathology
Toll-Like Receptor 3 / genetics
Toll-Like Receptor 3 / metabolism
Toll-Like Receptor 7 / genetics
Toll-Like Receptor 7 / metabolism*
Toll-Like Receptor 8 / genetics
Toll-Like Receptor 8 / metabolism*
Toll-Like Receptor 9 / genetics
Toll-Like Receptor 9 / metabolism
Tumor Necrosis Factor-alpha / blood

Substances

Blood Glucose
Cell Adhesion Molecules
IL6 protein, human
Interleukin-1beta
Interleukin-6
TLR3 protein, human
TLR7 protein, human
TLR8 protein, human
TLR9 protein, human
Toll-Like Receptor 3
Toll-Like Receptor 7
Toll-Like Receptor 8
Toll-Like Receptor 9
Tumor Necrosis Factor-alpha
C-Reactive Protein
Matrix Metalloproteinase 9