Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum

Mol Genet Metab. 2011 May;103(1):44-50. doi: 10.1016/j.ymgme.2011.01.018. Epub 2011 Feb 3.

Abstract

Arterial Calcification due to Deficiency of CD73 (ACDC) results from mutations in the NT5E gene encoding the 5' exonucleotidase, CD73. We now describe the third familial case of ACDC, including radiological and histopathological details of the arterial calcifications. The medial lesions involve the entire circumference of the elastic lamina, in contrast to the intimal plaque-like disease of atherosclerosis. The demonstration of broken and fragmented elastic fibers leading to generalized vascular calcification suggests an analogy to pseudoxanthoma elasticum (PXE), which exhibits similar histopathology. Classical PXE is caused by deficiency of ABCC6, a C type ABC transporter whose ligand is unknown. Other C type ABC proteins transport nucleotides, so the newly described role of adenosine in inhibiting vascular calcification, along with the similarity of ACDC and PXE with respect to vascular pathology, suggests that adenosine may be the ligand for ABCC6.

Publication types

  • Case Reports
  • Research Support, N.I.H., Intramural

MeSH terms

  • 5'-Nucleotidase / deficiency*
  • 5'-Nucleotidase / genetics
  • Adenosine / metabolism*
  • Adult
  • Arteries / pathology*
  • Calcinosis / diagnostic imaging
  • Calcinosis / pathology*
  • Female
  • Fibroblasts / metabolism
  • GPI-Linked Proteins / deficiency
  • GPI-Linked Proteins / genetics
  • Genotype
  • Humans
  • Models, Biological
  • Mutation / genetics
  • Pseudoxanthoma Elasticum / diagnostic imaging
  • Pseudoxanthoma Elasticum / metabolism*
  • Pseudoxanthoma Elasticum / pathology*
  • Radiography

Substances

  • GPI-Linked Proteins
  • 5'-Nucleotidase
  • NT5E protein, human
  • Adenosine