No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population

Atherosclerosis. 2011 Jun;216(2):381-2. doi: 10.1016/j.atherosclerosis.2011.02.005. Epub 2011 Mar 3.

Abstract

Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in three independent cohorts, including total of 3042 cases and 2973 controls. No significant association between these two SNPs and ischemic stroke was detected by meta-analysis after adjustment for cardiovascular risk factors under the additive model. Our data does not support that the common variants on 12p13 are major contributors of ischemic stroke in the Chinese Han population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Brain Ischemia / ethnology
  • Brain Ischemia / genetics*
  • Case-Control Studies
  • Cell Adhesion Molecules, Neuronal / genetics*
  • China
  • Cohort Studies
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Stroke / ethnology
  • Stroke / genetics*

Substances

  • Cell Adhesion Molecules, Neuronal
  • NINJ2 protein, human