p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?

Mario Pérez-Sayáns; José Manuel Suárez-Peñaranda; Pilar Gayoso-Diz; Francisco Barros-Angueira; José Manuel Gándara-Rey; Abel García-García

doi:10.1016/j.canlet.2011.02.039

p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?

Cancer Lett. 2011 Jul 28;306(2):134-41. doi: 10.1016/j.canlet.2011.02.039. Epub 2011 Mar 15.

Authors

Mario Pérez-Sayáns¹, José Manuel Suárez-Peñaranda, Pilar Gayoso-Diz, Francisco Barros-Angueira, José Manuel Gándara-Rey, Abel García-García

Affiliation

¹ Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, C.P. 15782, Spain. perezsayans@gmail.com

PMID: 21411222
DOI: 10.1016/j.canlet.2011.02.039

Abstract

Oral squamous cell carcinomas (OSCC) are the most common malignancy of the oral cavity and their multistep development requires the accumulation of multiple genetic and epigenetic alterations. Inactivation of p16(INK4a), encoded by the CDKN2 gene has been widely associated with this type of tumors. The purpose of this review is to elucidate the relationship between p16(INK4a) expression and the different clinical and pathological aspects of OSCC, analyze the variation in results between studies, detailing the described genetic/epigenetic alterations that result in gene silencing and the relationship between p16(INK4a) and HPV infection.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology
Cyclin-Dependent Kinase Inhibitor p16 / genetics*
Humans
Mouth Neoplasms / genetics*
Mouth Neoplasms / pathology
Prognosis

Substances

Cyclin-Dependent Kinase Inhibitor p16