Abstract
We discuss the clinical presentation, investigations carried out, and the management issues in an elderly patient with hemophagocytic lymphohistiocytosis (HLH). The HLH was associated with an underlying Epstein-Barr virus positive peripheral T-cell lymphoma, not otherwise specified, and the lymphomatous cells harbored translocation t(5;9)(q11.2:p24). The 9p24 region contains the JAK2 gene. The disease had a fulminant course.
Publication types
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Case Reports
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Clinical Conference
MeSH terms
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Aged
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Antibodies, Viral / immunology
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Chromosomes, Human, Pair 5 / genetics
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Chromosomes, Human, Pair 9 / genetics
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Diagnosis, Differential
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / diagnosis*
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Epstein-Barr Virus Infections / virology
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Fatal Outcome
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / immunology
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Hospitals
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Humans
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In Situ Hybridization
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Janus Kinase 2 / genetics
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London
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Lymphohistiocytosis, Hemophagocytic / diagnosis*
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Lymphohistiocytosis, Hemophagocytic / etiology
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Lymphoma, T-Cell, Peripheral / complications
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Lymphoma, T-Cell, Peripheral / diagnosis*
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Lymphoma, T-Cell, Peripheral / genetics
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Male
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RNA, Viral / genetics
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Translocation, Genetic
Substances
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Antibodies, Viral
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Epstein-Barr virus encoded RNA 1
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RNA, Viral
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JAK2 protein, human
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Janus Kinase 2