Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes

N Katakami; H Kaneto; M Takahara; T A Matsuoka; K Imamura; F Ishibashi; T Kanda; K Kawai; T Osonoi; M Matsuhisa; A Kashiwagi; R Kawamori; I Shimomura; Y Yamasaki

doi:10.1016/j.diabres.2011.02.017

Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes

Diabetes Res Clin Pract. 2011 Jun;92(3):e57-60. doi: 10.1016/j.diabres.2011.02.017. Epub 2011 Mar 21.

Authors

N Katakami¹, H Kaneto, M Takahara, T A Matsuoka, K Imamura, F Ishibashi, T Kanda, K Kawai, T Osonoi, M Matsuhisa, A Kashiwagi, R Kawamori, I Shimomura, Y Yamasaki

Affiliation

¹ Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. katakami@medone.med.osaka-u.ac.jp

PMID: 21420193
DOI: 10.1016/j.diabres.2011.02.017

Abstract

It is likely that the C allele of the polymorphism at position -106 in the promoter of aldose reductase gene, which codes a rate-limiting enzyme of the polyol pathway, is a susceptibility allele for diabetic retinopathy in Japanese type 2 diabetic patients.

MeSH terms

Aged
Aldehyde Reductase / genetics*
Alleles
Asian People
Diabetes Mellitus, Type 2 / genetics*
Diabetic Retinopathy / etiology*
Female
Genetic Predisposition to Disease / genetics
Humans
Male
Middle Aged
Polymorphism, Genetic / genetics*

Substances

Aldehyde Reductase