Entry at the trans-face of the Golgi

Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3):a005272. doi: 10.1101/cshperspect.a005272.

Abstract

The trans-Golgi network (TGN) receives a select set of proteins from the endocytic pathway-about 5% of total plasma membrane glycoproteins (Duncan and Kornfeld 1988). Proteins that are delivered include mannose 6-phosphate receptors (MPRs), TGN46, sortilin, and various toxins that hitchhike a ride backward through the secretory pathway to intoxicate cells after they exit into the cytoplasm from the endoplasmic reticulum (ER). This article will review work on the molecular players that drive protein transport from the endocytic pathway to the TGN. Distinct requirements have revealed multiple routes for retrograde transport; in addition, the existence of multiple, potential coat proteins and/or cargo adaptors imply that multiple vesicular transfers are likely involved. Several comprehensive reviews have appeared recently and should be sought for additional details (Bonifacino and Rojas 2006; Johannes and Popoff 2008).

Publication types

  • Review

MeSH terms

  • Models, Biological*
  • Protein Transport / physiology
  • Transport Vesicles / metabolism*
  • Vesicular Transport Proteins / metabolism*
  • rho GTP-Binding Proteins / metabolism
  • trans-Golgi Network / metabolism*
  • trans-Golgi Network / ultrastructure*

Substances

  • Vesicular Transport Proteins
  • RhoBTB3 protein, human
  • rho GTP-Binding Proteins