DNMT3A mutations in acute myeloid leukemia

Nat Genet. 2011 Mar 29;43(4):289-90. doi: 10.1038/ng0411-289.

Abstract

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

Publication types

  • News
  • Comment

MeSH terms

  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methylation
  • DNA Methyltransferase 3A
  • Epigenesis, Genetic
  • Hematopoiesis / genetics
  • Humans
  • Leukemia, Myeloid, Acute / enzymology*
  • Leukemia, Myeloid, Acute / genetics*
  • Models, Genetic
  • Mutation*

Substances

  • DNMT3A protein, human
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A