Does 24-h urinary MHPG predict treatment response to antidepressants? II. Association between imipramine response and low MHPG

M Garvey; R J DeRubeis; S D Hollon; M D Evans; V B Tuason

doi:10.1016/0165-0327(90)90142-u

Does 24-h urinary MHPG predict treatment response to antidepressants? II. Association between imipramine response and low MHPG

J Affect Disord. 1990 Nov;20(3):181-4. doi: 10.1016/0165-0327(90)90142-u.

Authors

M Garvey¹, R J DeRubeis, S D Hollon, M D Evans, V B Tuason

Affiliation

¹ Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

PMID: 2148338
DOI: 10.1016/0165-0327(90)90142-u

Abstract

Thirty depressed patients collected 24-h urine samples for a 3-methoxy-4-hydroxyphenylglycol (MHPG) determination prior to imipramine treatment. Patients responding to treatment had lower levels of MHPG than did non-responders.

MeSH terms

Adult
Depressive Disorder / drug therapy*
Depressive Disorder / psychology
Depressive Disorder / urine
Dose-Response Relationship, Drug
Female
Humans
Imipramine / administration & dosage
Imipramine / therapeutic use*
Male
Methoxyhydroxyphenylglycol / urine*
Psychiatric Status Rating Scales

Substances

Methoxyhydroxyphenylglycol
Imipramine