Cholesteryl ester transfer protein: the controversial relation to atherosclerosis and emerging new biological roles

IUBMB Life. 2011 Apr;63(4):248-57. doi: 10.1002/iub.448.

Abstract

Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipogenesis
  • Alzheimer Disease / metabolism
  • Animals
  • Atherosclerosis / drug therapy
  • Atherosclerosis / metabolism*
  • Cholesterol / metabolism
  • Cholesterol Ester Transfer Proteins / antagonists & inhibitors
  • Cholesterol Ester Transfer Proteins / genetics
  • Cholesterol Ester Transfer Proteins / metabolism*
  • Clinical Trials as Topic
  • Humans
  • Inflammation / metabolism
  • Lipoproteins / metabolism
  • Mutation
  • Obesity / metabolism
  • Oxidation-Reduction

Substances

  • Cholesterol Ester Transfer Proteins
  • Lipoproteins
  • Cholesterol