DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Behav Brain Res. 2011 Sep 30;223(1):36-41. doi: 10.1016/j.bbr.2011.04.007. Epub 2011 Apr 12.

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Brain Mapping / methods
  • Cerebral Cortex / physiology*
  • Corpus Striatum / physiology*
  • Emotions / physiology*
  • Facial Expression*
  • Female
  • Genotype
  • Humans
  • Magnetic Resonance Imaging / methods
  • Neural Pathways / physiology
  • Photic Stimulation / methods
  • Polymorphism, Restriction Fragment Length
  • Protein Serine-Threonine Kinases / genetics*
  • Receptors, Dopamine D2 / genetics*

Substances

  • Receptors, Dopamine D2
  • ANKK1 protein, human
  • Protein Serine-Threonine Kinases