Abstract
Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc.
MeSH terms
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Animals
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Antigens, Polyomavirus Transforming / metabolism
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Apoptosis
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Gene Expression Regulation, Neoplastic
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Genes, myc / genetics
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Humans
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Neoplasms / blood supply
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Neoplasms / physiopathology*
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism*
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Tumor Microenvironment / physiology
Substances
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Antigens, Polyomavirus Transforming
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Proto-Oncogene Proteins c-myc