The relationship of plasminogen activators and oncogenes to tumour invasion

J S Gelister; P B Boulos; P J Gaffney; M Mahmoud; M R Lewin

The relationship of plasminogen activators and oncogenes to tumour invasion

Eur J Surg Oncol. 1990 Feb;16(1):54-9.

Authors

J S Gelister¹, P B Boulos, P J Gaffney, M Mahmoud, M R Lewin

Affiliation

¹ Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.

PMID: 2155139

Abstract

Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.

Publication types

Review

MeSH terms

Cell Division
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
Humans
Neoplasm Invasiveness / physiopathology*
Neoplasm Metastasis
Oncogenes*
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols / metabolism
Plasminogen Activators / physiology*

Substances

Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols
Plasminogen Activators