Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern

Eur Psychiatry. 2012 Jul;27(5):369-71. doi: 10.1016/j.eurpsy.2011.02.011. Epub 2011 May 11.

Abstract

This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.

MeSH terms

  • Case-Control Studies
  • Female
  • Genes, X-Linked*
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Introns*
  • Male
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Receptors, G-Protein-Coupled / genetics*
  • Seasonal Affective Disorder / genetics*
  • Sex Factors

Substances

  • GPR50 protein, human
  • Nerve Tissue Proteins
  • Receptors, G-Protein-Coupled