p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia

Akira Yokoyama; Yoichi Tanaka; Tetsuji Yokoyama; Takeshi Mizukami; Toshifumi Matsui; Katsuya Maruyama; Tai Omori

doi:10.1016/j.canlet.2011.04.020

p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia

Cancer Lett. 2011 Sep 1;308(1):112-7. doi: 10.1016/j.canlet.2011.04.020. Epub 2011 May 23.

Authors

Akira Yokoyama¹, Yoichi Tanaka, Tetsuji Yokoyama, Takeshi Mizukami, Toshifumi Matsui, Katsuya Maruyama, Tai Omori

Affiliation

¹ National Hospital Organization, Kurihama Alcoholism Center, Kanagawa, Japan. a_yokoyama@kurihama1.hosp.go.jp

PMID: 21601984
DOI: 10.1016/j.canlet.2011.04.020

Abstract

Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus. We studied 260 esophageal-cancer free Japanese alcoholics with esophageal dysplasia diagnosed by biopsy of distinct iodine-unstained lesions (DIULs) ≥5mm. The degree of p53 protein accumulation was positively associated with the degree of atypia (p<0.0001) and size (p=0.040) of DIULs and with the presence of multiple DIULs (p=0.070), but not with ALDH2(*)1/(*)2 or ADH1B(*)1/(*)1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Alcohol Dehydrogenase / genetics*
Alcohol Dehydrogenase / metabolism
Alcoholism / genetics
Alcoholism / metabolism*
Alcoholism / pathology
Aldehyde Dehydrogenase / genetics*
Aldehyde Dehydrogenase / metabolism
Aldehyde Dehydrogenase, Mitochondrial
Asian People
Esophageal Diseases / enzymology
Esophageal Diseases / genetics
Esophageal Diseases / metabolism*
Esophageal Diseases / pathology
Esophageal Neoplasms / enzymology
Esophageal Neoplasms / genetics
Esophageal Neoplasms / metabolism*
Esophageal Neoplasms / pathology
Genotype
Humans
Male
Middle Aged
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

TP53 protein, human
Tumor Suppressor Protein p53
ADH1B protein, human
Alcohol Dehydrogenase
ALDH2 protein, human
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial