Abstract
A 45-year-old man with heterozygous Factor V Leiden presented with his third cerebrovascular accident despite being on warfarin at a therapeutic international normalized ratio. Subsequent investigation revealed a second genetic diagnosis of Fabry disease. He then had an acute myocardial infarction whilst on aspirin and warfarin.
© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.
MeSH terms
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Activated Protein C Resistance / genetics*
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Aspirin / therapeutic use
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Atorvastatin
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Coronary Stenosis / complications
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Coronary Stenosis / therapy
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Defibrillators, Implantable
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Drug Therapy, Combination
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Enzyme Replacement Therapy
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Fabry Disease / complications*
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Factor V / genetics*
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Heptanoic Acids / therapeutic use
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Hypercholesterolemia / complications
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Hypercholesterolemia / drug therapy
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Male
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Metoprolol / therapeutic use
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Middle Aged
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Perindopril / therapeutic use
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Pyrroles / therapeutic use
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Quality of Life
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Recurrence
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Sequence Deletion
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Stents
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Stroke / drug therapy
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Stroke / etiology
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Stroke / genetics
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Stroke / prevention & control
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Stroke Rehabilitation
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Thrombophilia / etiology*
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Thrombophilia / genetics
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Warfarin / therapeutic use
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alpha-Galactosidase / blood
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alpha-Galactosidase / genetics
Substances
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Heptanoic Acids
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Pyrroles
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factor V Leiden
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Warfarin
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Factor V
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Atorvastatin
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alpha-Galactosidase
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Metoprolol
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Aspirin
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Perindopril