Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report

Psychiatry Res. 2011 Nov 30;190(1):149-51. doi: 10.1016/j.psychres.2011.04.027. Epub 2011 May 31.

Abstract

We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in TPH2, and suicidal behaviour in 150 alcohol-dependent patients. There was a significant association between more frequent C102C genotype in HTR2A and suicide attempts in alcoholic females. No differences in genotype distribution in HTR1A and TPH2 SNPs were found between patients with and without suicide attempts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Alcoholism / genetics*
  • Alcoholism / psychology*
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Receptor, Serotonin, 5-HT1A / genetics*
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Suicide, Attempted*
  • Tryptophan Hydroxylase / genetics*
  • Young Adult

Substances

  • Receptor, Serotonin, 5-HT2A
  • Receptor, Serotonin, 5-HT1A
  • TPH2 protein, human
  • Tryptophan Hydroxylase