Abstract
Kinetochores are large proteinaceous complexes that physically link centromeric DNA to the plus ends of spindle microtubules. Stable kinetochore-microtubule attachments are a prerequisite for the accurate and efficient distribution of genetic material over multiple generations. In the past decade, concerted research has resulted in the identification of the individual kinetochore building blocks, the characterization of critical microtubule-interacting components, such as the NDC80 complex, and the development of an approximate model of the architecture of this sophisticated biological machine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism
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Cell Division
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Centromere / genetics
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Centromere / metabolism
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Cytoskeletal Proteins
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Evolution, Molecular
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Humans
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Kinetochores / metabolism*
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / metabolism
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Microtubules / metabolism*
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Protein Binding
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / metabolism
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Spindle Apparatus / metabolism*
Substances
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Caenorhabditis elegans Proteins
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Cytoskeletal Proteins
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Microtubule-Associated Proteins
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NDC-80 protein, C elegans
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NDC80 protein, human
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins