Abstract
Transposition of the abl gene was demonstrated in seven Philadelphia (Ph'-) negative patients with either chronic myeloid leukaemia (CML) or acute lymphocytic leukaemia (ALL) by chromosomal in situ hybridization. In six out of seven CML patients and one out of two ALL patients, a significant accumulation of abl hybridization grains was localized to chromosome 22. Hybridization with both abl and sis resulted in the consistent formation of double hybridization events on chromosome 22. Transposition of abl was not apparent in one patient with Ph'-negative CML and in one patient with Ph'-negative ALL. The data suggest that transposition of abl to chromosome 22 is a feature of a particular subgroup of Ph'-negative leukaemias.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosome Mapping
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Chromosomes / analysis
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Chromosomes / drug effects
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Chromosomes / ultrastructure
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DNA Transposable Elements*
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DNA, Neoplasm / analysis
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DNA, Neoplasm / genetics
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Humans
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Karyotyping
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics*
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology
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Male
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Platelet-Derived Growth Factor / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-abl
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Proto-Oncogene Proteins c-sis
Substances
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DNA Transposable Elements
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DNA, Neoplasm
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MAS1 protein, human
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Platelet-Derived Growth Factor
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-sis
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Proto-Oncogene Proteins c-abl