GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism

Edyta Reszka; Zbigniew Jabłonowski; Edyta Wieczorek; Jolanta Gromadzińska; Marek Sosnowski; Wojciech Wąsowicz

doi:10.1016/j.clinbiochem.2011.05.024

GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism

Clin Biochem. 2011 Sep;44(13):1153-1155. doi: 10.1016/j.clinbiochem.2011.05.024. Epub 2011 Jun 12.

Authors

Edyta Reszka¹, Zbigniew Jabłonowski², Edyta Wieczorek³, Jolanta Gromadzińska³, Marek Sosnowski², Wojciech Wąsowicz³

Affiliations

¹ Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. Electronic address: edyta@imp.lodz.pl.
² I Department of Urology, Medical University, Lodz, Poland.
³ Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.

PMID: 21669193
DOI: 10.1016/j.clinbiochem.2011.05.024

Abstract

Objectives: We explored association between GSTP1 Ile(105)Val (rs1695) polymorphism and GSTP1 mRNA expression in circulating blood leukocytes.

Design and methods: GSTP1 transcripts level and polymorphism were determined by Real-Time PCR in 51 bladder cancer and 90 healthy men.

Results: Individuals with at least one GSTP1 Val(105) variant allele possessed higher GSTP1 mRNA level in blood leukocytes compared to GSTP1 Ile(105)Ile carriers.

Conclusions: GSTP1 Ile(105)Val gene polymorphism influences its expression in blood, regardless of cancer disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Blood Cells
Case-Control Studies
Gene Expression
Glutathione S-Transferase pi / blood*
Glutathione S-Transferase pi / genetics*
Humans
Leukocytes / metabolism*
Male
Middle Aged
Polymorphism, Genetic*
RNA, Messenger / analysis*
Urinary Bladder Neoplasms

Substances

RNA, Messenger
GSTP1 protein, human
Glutathione S-Transferase pi