Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides

Yohei Ueno; Takanobu Sakurai; Shinji Okada; Keiko Abe; Takumi Misaka

doi:10.1271/bbb.100893

Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides

Biosci Biotechnol Biochem. 2011;75(6):1188-90. doi: 10.1271/bbb.100893. Epub 2011 Jun 13.

Authors

Yohei Ueno¹, Takanobu Sakurai, Shinji Okada, Keiko Abe, Takumi Misaka

Affiliation

¹ Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

PMID: 21670512
DOI: 10.1271/bbb.100893

Abstract

The strong bitter peptide, Phe-Phe-Pro-Arg, activated cultured cells expressing either of the known human bitter taste receptors, hTAS2R8 and hTAS2R39. The partial structure of Pro-Arg activated hTAS2R39, but did not activate hTAS2R8. These receptors may not indiscriminately recognize bitter peptides, but have a differential function in their recognition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dipeptides / pharmacology
Gene Expression*
HEK293 Cells
Humans
Microscopy, Fluorescence
Oligopeptides / pharmacology
Plasmids
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism*
Receptors, G-Protein-Coupled
Recombinant Fusion Proteins / genetics
Recombinant Fusion Proteins / metabolism*
Structure-Activity Relationship
Taste / drug effects
Taste / physiology*
Transfection

Substances

Dipeptides
Oligopeptides
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Recombinant Fusion Proteins
TAS2R39 protein, human
TAS2R8 protein, human
prolylarginine
phenylalanyl-prolyl-arginine