Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia

J Clin Immunol. 2011 Oct;31(5):744-51. doi: 10.1007/s10875-011-9554-2. Epub 2011 Jun 14.

Abstract

T cell chemotaxis to sphingosine 1-phosphate (S1P) and the chemokines CCL21 and CCL5 was studied in ten adults with T lymphocytopenia, other immunological abnormalities (nine of ten), and frequent bacterial infections (seven of ten). Mean chemotactic responses to S1P of CD4 T cells from CD4 T lymphocytopenic patients and of CD8 T cells from CD8 T lymphocytopenic patients were significantly lower than those of healthy matched controls. Chemotaxis to CCL21 was lower than that of controls for CD4 T cells of three CD4 T lymphocytopenic patients and for CD8 T cells of three CD8 T lymphocytopenic patients, but none of the T cells of patients had diminished chemotaxis to CCL5. Defective T cell chemotactic responses to S1P and some chemokines may lead to subset-selective abnormal T cell trafficking and chronic T cell lymphocytopenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / blood
  • Bacterial Infections
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism*
  • CD4-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism*
  • CD8-Positive T-Lymphocytes / pathology
  • Cells, Cultured
  • Chemokine CCL21 / immunology
  • Chemokine CCL5 / immunology
  • Chemotaxis
  • Humans
  • Immunoglobulin M / blood
  • Lymphopenia / diagnosis
  • Lymphopenia / immunology*
  • Lymphopenia / pathology
  • Lymphopenia / physiopathology
  • Lysophospholipids / immunology
  • Male
  • Middle Aged
  • Receptors, CCR7 / genetics
  • Receptors, CCR7 / immunology
  • Receptors, CCR7 / metabolism
  • Receptors, Lysosphingolipid / genetics
  • Receptors, Lysosphingolipid / immunology
  • Receptors, Lysosphingolipid / metabolism*
  • Recurrence
  • Sphingosine / analogs & derivatives
  • Sphingosine / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism*
  • T-Lymphocyte Subsets / pathology

Substances

  • Autoantibodies
  • CCR7 protein, human
  • Chemokine CCL21
  • Chemokine CCL5
  • Immunoglobulin M
  • Lysophospholipids
  • Receptors, CCR7
  • Receptors, Lysosphingolipid
  • sphingosine 1-phosphate
  • Sphingosine