Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects

J Neuroimmunol. 2011 Aug 15;237(1-2):39-46. doi: 10.1016/j.jneuroim.2011.05.013. Epub 2011 Jun 29.

Abstract

Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Cells, Cultured
  • Humans
  • Inflammation Mediators / physiology*
  • Interleukin-1beta / agonists
  • Interleukin-1beta / physiology*
  • Neuritis / immunology
  • Neuritis / pathology*
  • Neuroglia / immunology
  • Neuroglia / metabolism
  • Rats
  • Rats, Wistar
  • Receptors, Calcitonin Gene-Related Peptide / biosynthesis*
  • Receptors, Calcitonin Gene-Related Peptide / genetics
  • Receptors, Calcitonin Gene-Related Peptide / metabolism
  • Satellite Cells, Perineuronal / immunology
  • Satellite Cells, Perineuronal / metabolism*
  • Sensory Receptor Cells / immunology
  • Sensory Receptor Cells / metabolism*
  • Trigeminal Ganglion / cytology
  • Trigeminal Ganglion / immunology
  • Trigeminal Ganglion / metabolism*
  • Up-Regulation / immunology*

Substances

  • Inflammation Mediators
  • Interleukin-1beta
  • Receptors, Calcitonin Gene-Related Peptide