Abstract
Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Cells, Cultured
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Humans
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Inflammation Mediators / physiology*
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Interleukin-1beta / agonists
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Interleukin-1beta / physiology*
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Neuritis / immunology
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Neuritis / pathology*
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Neuroglia / immunology
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Neuroglia / metabolism
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Rats
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Rats, Wistar
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Receptors, Calcitonin Gene-Related Peptide / biosynthesis*
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Receptors, Calcitonin Gene-Related Peptide / genetics
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Receptors, Calcitonin Gene-Related Peptide / metabolism
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Satellite Cells, Perineuronal / immunology
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Satellite Cells, Perineuronal / metabolism*
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Sensory Receptor Cells / immunology
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Sensory Receptor Cells / metabolism*
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Trigeminal Ganglion / cytology
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Trigeminal Ganglion / immunology
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Trigeminal Ganglion / metabolism*
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Up-Regulation / immunology*
Substances
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Inflammation Mediators
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Interleukin-1beta
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Receptors, Calcitonin Gene-Related Peptide