Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report

Taro Ohba; Kenji Sugio; Takuro Kometani; Masafumi Yamaguchi; Motoharu Hamatake; Kaname Nosaki; Hiroaki Takeoka; Hiromoto Kitajima; Fumihiko Hirai; Takashi Seto; Kenichi Taguchi; Kenichi Nishiyama; Yoshitaka Shida; Yukito Ichinose

doi:10.1016/j.lungcan.2011.05.016

Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report

Lung Cancer. 2011 Sep;73(3):375-8. doi: 10.1016/j.lungcan.2011.05.016. Epub 2011 Jun 29.

Authors

Taro Ohba¹, Kenji Sugio, Takuro Kometani, Masafumi Yamaguchi, Motoharu Hamatake, Kaname Nosaki, Hiroaki Takeoka, Hiromoto Kitajima, Fumihiko Hirai, Takashi Seto, Kenichi Taguchi, Kenichi Nishiyama, Yoshitaka Shida, Yukito Ichinose

Affiliation

¹ Department of Thoracic Oncology, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan.

PMID: 21719143
DOI: 10.1016/j.lungcan.2011.05.016

Abstract

We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21 mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4-ALK gene.

Publication types

Case Reports

MeSH terms

Adenocarcinoma, Mucinous / diagnosis*
Adenocarcinoma, Mucinous / genetics
Adenocarcinoma, Mucinous / pathology
Adenocarcinoma, Mucinous / physiopathology
Adenocarcinoma, Mucinous / surgery
Aged
Carcinoembryonic Antigen / blood
Carcinoma, Signet Ring Cell / diagnosis*
Carcinoma, Signet Ring Cell / genetics
Carcinoma, Signet Ring Cell / pathology
Carcinoma, Signet Ring Cell / physiopathology
Carcinoma, Signet Ring Cell / surgery
Chest Pain
DNA Mutational Analysis
Diagnosis, Differential
Disease Progression
Disease-Free Survival
Female
Humans
Lung / diagnostic imaging
Lung / metabolism*
Lung / pathology
Lung Neoplasms / diagnosis*
Lung Neoplasms / genetics
Lung Neoplasms / pathology
Lung Neoplasms / physiopathology
Lung Neoplasms / surgery
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism*
Pneumonectomy
Radiography
Radionuclide Imaging

Substances

Carcinoembryonic Antigen
EML4-ALK fusion protein, human
Oncogene Proteins, Fusion