Abstract
The retromer complex coordinates retrograde transport of cargo proteins between endosomes and the trans-Golgi network. The sorting nexin SNX3 is required for the retrograde trafficking of Wntless, but not of other retrograde cargo proteins, revealing that the cargo specificity of retromer is provided by the sorting nexins.
MeSH terms
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Animals
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Biological Transport, Active
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Endosomes / metabolism*
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Models, Biological
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Sorting Nexins / metabolism*
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Wnt Proteins / metabolism
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trans-Golgi Network / metabolism
Substances
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Intracellular Signaling Peptides and Proteins
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Sorting Nexins
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Wnt Proteins