Abstract
This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) were documented in patients with endometriosis-associated infertility versus controls, and in patients with endometriosis versus controls, respectively. In women who have the risk genotype at both single-nucleotide polymorphisms, the estimated risk for endometriosis nearly doubled.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Amino Acid Oxidoreductases / genetics*
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Case-Control Studies
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Chi-Square Distribution
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Complement C3 / genetics*
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Endometriosis / complications
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Endometriosis / enzymology
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Endometriosis / genetics*
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Endometriosis / immunology
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Humans
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Infertility, Female / enzymology
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Infertility, Female / genetics*
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Infertility, Female / immunology
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Linkage Disequilibrium
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Odds Ratio
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Phenotype
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Polymorphism, Single Nucleotide*
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Protein-Lysine 6-Oxidase
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Puerto Rico
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Risk Assessment
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Risk Factors
Substances
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C3 protein, human
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Complement C3
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Amino Acid Oxidoreductases
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LOXL4 protein, human
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Protein-Lysine 6-Oxidase