Abstract
Fibroblast growth factor receptor 2 (FGFR2) is considered a novel therapeutic target for various cancer. We used a silencing strategy to clarify the effect of reduced FGFR2 expression in human colorectal cancer (CRC) cells. The invasive front of cancer cells exhibited stronger FGFR2 expression than the surface area of the cancers. FGFR2 shRNA-transfected LoVo cells inhibited cell migration, invasion and tumor growth in vitro and in vivo. Thus, FGFR2 plays important roles in CRC progression in association with tumor cell migration, invasion and growth, and FGFR2 might be a novel therapeutic target for CRC.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Animals
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Antibodies, Monoclonal
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Cell Adhesion
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Cell Movement / genetics
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Cell Proliferation
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / metabolism*
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / therapy*
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Disease Progression
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Extracellular Matrix
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Female
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Flow Cytometry
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Gene Expression Regulation, Neoplastic
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Humans
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Male
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Mice
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Mice, Nude
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Middle Aged
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Neoplasm Invasiveness
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Polymerase Chain Reaction
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RNA Interference
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RNA, Small Interfering / pharmacology*
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Receptor, Fibroblast Growth Factor, Type 2 / genetics
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Receptor, Fibroblast Growth Factor, Type 2 / immunology
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Receptor, Fibroblast Growth Factor, Type 2 / metabolism*
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Signal Transduction
Substances
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Antibodies, Monoclonal
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RNA, Small Interfering
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Receptor, Fibroblast Growth Factor, Type 2