How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?

Amelie Fassbender; Lut Overbergh; Eefje Verdrengh; Cleophas M Kyama; Alexandra Vodolazakaia; Attila Bokor; Christel Meuleman; Karen Peeraer; Carla Tomassetti; Etienne Waelkens; Chantal Mathieu; Thomas D'Hooghe

doi:10.1016/j.fertnstert.2011.06.034

How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?

Fertil Steril. 2011 Sep;96(3):697-9. doi: 10.1016/j.fertnstert.2011.06.034. Epub 2011 Jul 16.

Authors

Amelie Fassbender¹, Lut Overbergh, Eefje Verdrengh, Cleophas M Kyama, Alexandra Vodolazakaia, Attila Bokor, Christel Meuleman, Karen Peeraer, Carla Tomassetti, Etienne Waelkens, Chantal Mathieu, Thomas D'Hooghe

Affiliation

¹ Leuven University Fertility Centre, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium.

PMID: 21762896
DOI: 10.1016/j.fertnstert.2011.06.034

Abstract

This study indicates that the immunobiology of macroscopically normal peritoneum is relevant to understand the pathogenesis of endometriosis. Peritoneal interleukin 6, interleukin 12, and ferritin were differentially expressed in women with and without endometriosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endometriosis / etiology*
Endometriosis / pathology*
Endometriosis / physiopathology
Female
Ferritins / genetics
Gene Expression / immunology
Gene Expression Profiling*
Humans
Interleukin-12 / genetics
Interleukin-6 / genetics
Menstrual Cycle / physiology
Peritoneum / immunology*
Peritoneum / pathology*
Reverse Transcriptase Polymerase Chain Reaction

Substances

IL6 protein, human
Interleukin-6
Interleukin-12
Ferritins