TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation

Gabriela Dos Santos Hidalgo; Juliana Meola; Júlio César Rosa E Silva; Cláudia Cristina Paro de Paz; Rui Alberto Ferriani

doi:10.1016/j.fertnstert.2011.06.052

TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation

Fertil Steril. 2011 Sep;96(3):700-3. doi: 10.1016/j.fertnstert.2011.06.052. Epub 2011 Jul 20.

Authors

Gabriela Dos Santos Hidalgo¹, Juliana Meola, Júlio César Rosa E Silva, Cláudia Cristina Paro de Paz, Rui Alberto Ferriani

Affiliation

¹ Department of Gynecology and Obstetrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. ghidalgo@usp.br

PMID: 21763649
DOI: 10.1016/j.fertnstert.2011.06.052

Abstract

We found an increased expression of the TAGLN gene in endometriotic lesions compared with the eutopic endometrium of the same patients by real-time polymerase chain reaction. It is possible that this deregulation contributes to the development and maintenance of endometriosis by being involved in the pathways of organization of cytoskeletal architecture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cell Differentiation / physiology
Cell Movement / physiology*
Endometriosis / pathology*
Endometriosis / physiopathology*
Endometrium / physiology*
Female
Gene Expression Regulation / physiology
Humans
Microfilament Proteins / genetics*
Middle Aged
Muscle Proteins / genetics*
Ovarian Diseases / pathology
Ovarian Diseases / physiopathology
Peritoneal Diseases / pathology
Peritoneal Diseases / physiopathology
Reverse Transcriptase Polymerase Chain Reaction
Young Adult

Substances

Microfilament Proteins
Muscle Proteins
transgelin