Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder

John P Houston; Jared Kohler; Katherine M Ostbye; Alexandra Heinloth; Roy H Perlis

doi:10.1016/j.psychres.2011.07.002

Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder

Psychiatry Res. 2011 Oct 30;189(3):475-7. doi: 10.1016/j.psychres.2011.07.002. Epub 2011 Jul 24.

Authors

John P Houston¹, Jared Kohler, Katherine M Ostbye, Alexandra Heinloth, Roy H Perlis

Affiliation

¹ Neuroscience Department, Eli Lilly and Company, LLC, Indianapolis, IN, USA. houston_jonh_p@lilly.com

PMID: 21788083
DOI: 10.1016/j.psychres.2011.07.002

Abstract

Single-nucleotide and diplotype associations with 17-item Hamilton Depression Rating Scale (HAMD(17)) total score changes were examined, based on catechol-O-methyltransferase (COMT) rs165599 status in duloxetine-treated, self-identified white patients with major depressive disorder. COMT rs165737 and a diplotype containing COMT rs165599 and COMT rs165737 were associated with HAMD(17) total score changes.

MeSH terms

Adult
Antidepressive Agents / therapeutic use*
Catechol O-Methyltransferase / genetics*
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics*
Duloxetine Hydrochloride
Female
Genome-Wide Association Study
Humans
Male
Middle Aged
Pharmacogenetics
Polymorphism, Single Nucleotide / genetics
Psychiatric Status Rating Scales
Sex Factors
Thiophenes / therapeutic use*

Substances

Antidepressive Agents
Thiophenes
Duloxetine Hydrochloride
Catechol O-Methyltransferase