Proteasome modulator 9 and carpal tunnel syndrome

Claudia Gragnoli

doi:10.1016/j.diabres.2011.07.040

Proteasome modulator 9 and carpal tunnel syndrome

Diabetes Res Clin Pract. 2011 Nov;94(2):e47-9. doi: 10.1016/j.diabres.2011.07.040. Epub 2011 Sep 8.

Author

Claudia Gragnoli¹

Affiliation

¹ Laboratory of Molecular Genetics of Complex and Monogenic Disorders, Department of Medicine and Cellular & Molecular Physiology and Biostatistics, Penn State University and MS Hershey Medical Center, Hershey, PA 17033, United States. claudia.gragnoli@gmail.com

PMID: 21862167
DOI: 10.1016/j.diabres.2011.07.040

Abstract

Proteasome modulator 9 (PSMD9) is linked to type 2 diabetes (T2D). The author studied whether PSMD9 IVS3 + nt460 A > G, IVS3 + nt437 T > C and E197 are linked to carpal tunnel syndrome in T2D Italian families. Non-parametric linkage, linkage disequilibrium-based and independent SNPs-based linkage analyses were performed. The PSMD9 SNPs show linkage to carpal tunnel syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carpal Tunnel Syndrome / epidemiology
Carpal Tunnel Syndrome / genetics*
Diabetes Complications / epidemiology
Diabetes Complications / genetics*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / genetics*
Gene Frequency
Genetic Predisposition to Disease
Humans
Italy / epidemiology
Linkage Disequilibrium
Lod Score
Phenotype
Polymorphism, Single Nucleotide*
Prevalence
Proteasome Endopeptidase Complex / genetics*
Risk Assessment
Risk Factors

Substances

PSMD9 protein, human
Proteasome Endopeptidase Complex