Abstract
Iron disorders of genetic origin are mainly composed of iron overload diseases, the most frequent being HFE-related hemochromatosis. Hepcidin deficiency underlies iron overload in HFE-hemochromatosis as well as in several other genetic iron excess disorders, such as hemojuvelin or hepcidin-related hemochromatosis and transferrin receptor 2-related hemochromatosis. Deficiency of ferroportin, the only known cellular protein iron exporter, produces iron overload in the typical form of ferroportin disease. By contrast, genetically enhanced hepcidin production, as observed in matriptase-2 deficiency, generates iron-refractory iron deficiency anemia. Diagnosis of these iron storage disorders is usually established noninvasively through combined biochemical, imaging and genetic approaches. Moreover, improved knowledge of the molecular mechanisms accounting for the variations of iron stores opens the way of novel therapeutic approaches aiming to restore normal iron homeostasis. In this review, we will summarize recent findings about these various genetic entities that have been identified owing to an exemplary interplay between clinicians and basic scientists.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anemia, Iron-Deficiency / blood
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Anemia, Iron-Deficiency / diagnosis
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Anemia, Iron-Deficiency / genetics*
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Anemia, Iron-Deficiency / physiopathology
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Animals
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Antimicrobial Cationic Peptides / blood
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Cation Transport Proteins / deficiency
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Cation Transport Proteins / genetics*
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GPI-Linked Proteins / genetics*
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Genes, Dominant
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Genes, Recessive
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Genetic Testing
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Hemochromatosis / blood
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Hemochromatosis / diagnosis
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Hemochromatosis / genetics*
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Hemochromatosis / physiopathology
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Hemochromatosis Protein
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Hepcidins
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Histocompatibility Antigens Class I / genetics*
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Homeostasis / physiology
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Humans
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Iron / metabolism*
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Magnetic Resonance Imaging
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Membrane Proteins / deficiency
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Membrane Proteins / genetics*
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Mice
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Mutation
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Rats
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Receptors, Transferrin
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Serine Endopeptidases / deficiency
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Serine Endopeptidases / genetics*
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Signal Transduction
Substances
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Antimicrobial Cationic Peptides
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Cation Transport Proteins
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GPI-Linked Proteins
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HAMP protein, human
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HFE protein, human
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HJV protein, human
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Hamp protein, mouse
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Hamp protein, rat
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Hemochromatosis Protein
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Hepcidins
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Histocompatibility Antigens Class I
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Membrane Proteins
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Receptors, Transferrin
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TFR2 protein, human
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metal transporting protein 1
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solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
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Iron
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Serine Endopeptidases
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matriptase 2