COMT haplotype analyses in Malaysians with schizophrenia

Shiau Foon Tee; Pek Yee Tang; Han Chern Loh

doi:10.1016/j.psychres.2011.07.039

COMT haplotype analyses in Malaysians with schizophrenia

Psychiatry Res. 2012 Jan 30;195(1-2):83-4. doi: 10.1016/j.psychres.2011.07.039. Epub 2011 Aug 27.

Authors

Shiau Foon Tee¹, Pek Yee Tang, Han Chern Loh

Affiliation

¹ Department of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia.

PMID: 21872942
DOI: 10.1016/j.psychres.2011.07.039

Abstract

The present study included a total 261 patients with schizophrenia and 261 healthy controls to replicate the genetic association between the cathechol-o-methyltransferase gene and schizophrenia using a haplotype block-based gene-tagging. The G-G-G haplotype was found to show a highly significant association with schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Catechol O-Methyltransferase / genetics*
Chi-Square Distribution
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Malaysia / ethnology
Male
Polymorphism, Single Nucleotide / genetics*
Psychiatric Status Rating Scales
Schizophrenia / ethnology
Schizophrenia / genetics*
Young Adult

Substances

Catechol O-Methyltransferase