Protein export at the ER: loading big collagens into COPII carriers

Vivek Malhotra; Patrik Erlmann

doi:10.1038/emboj.2011.255

Protein export at the ER: loading big collagens into COPII carriers

EMBO J. 2011 Aug 31;30(17):3475-80. doi: 10.1038/emboj.2011.255.

Authors

Vivek Malhotra¹, Patrik Erlmann

Affiliation

¹ ICREA, Barcelona, Spain. vivek.malhotra@crg.eu

Abstract

COPII vesicles mediate the export of secretory cargo from endoplasmic reticulum (ER) exit sites. However, of 60-90 nm diameter COPII vesicles are too small to accommodate secreted molecules such as the collagens. The ER exit site-located proteins TANGO1 and cTAGE5 are required for the transport of collagens and therefore provide a means to understand the export of big cargo and the mechanism of COPII carrier size regulation commensurate with cargo dimensions.

Publication types

Review

MeSH terms

Animals
Antigens, Neoplasm / metabolism
Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism
COP-Coated Vesicles / metabolism*
Collagen / metabolism*
Drosophila / metabolism
Drosophila Proteins / metabolism
Endoplasmic Reticulum / metabolism*
Golgi Apparatus / metabolism
Humans
Mice
Neoplasm Proteins / metabolism
Protein Transport / physiology

Substances

Antigens, Neoplasm
Drosophila Proteins
MIA2 protein, human
Neoplasm Proteins
tgo protein, Drosophila
Aryl Hydrocarbon Receptor Nuclear Translocator
Collagen