Ribosomal protein metallopanstimulin-1 impairs multiple myeloma CAG cells growth and inhibits fibroblast growth factor receptor 3

Clin Lymphoma Myeloma Leuk. 2011 Dec;11(6):490-7. doi: 10.1016/j.clml.2011.06.015. Epub 2011 Sep 1.

Abstract

Introduction: It was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.

Methods: The present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.

Results: Overexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.

Conclusions: These data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Growth Processes / physiology
  • Cell Line, Tumor
  • Culture Media, Conditioned
  • Fibroblast Growth Factors / metabolism
  • Gene Expression Profiling
  • Humans
  • MAP Kinase Signaling System
  • Male
  • Metalloproteins / biosynthesis*
  • Metalloproteins / genetics
  • Metalloproteins / pharmacology
  • Mice
  • Mice, Nude
  • Multiple Myeloma / genetics
  • Multiple Myeloma / metabolism*
  • Multiple Myeloma / pathology
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / pharmacology
  • RNA-Binding Proteins / biosynthesis*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / pharmacology
  • Receptor, Fibroblast Growth Factor, Type 3 / antagonists & inhibitors*
  • Receptor, Fibroblast Growth Factor, Type 3 / biosynthesis
  • Receptor, Fibroblast Growth Factor, Type 3 / genetics
  • Ribosomal Proteins / biosynthesis*
  • Ribosomal Proteins / genetics
  • Ribosomal Proteins / pharmacology
  • Signal Transduction
  • Transfection
  • Transplantation, Heterologous

Substances

  • Culture Media, Conditioned
  • Metalloproteins
  • Nuclear Proteins
  • RNA-Binding Proteins
  • RPS27 protein, human
  • Ribosomal Proteins
  • Fibroblast Growth Factors
  • Receptor, Fibroblast Growth Factor, Type 3