Abstract
Introduction:
It was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.
Methods:
The present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.
Results:
Overexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.
Conclusions:
These data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / physiology
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Cell Growth Processes / physiology
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Cell Line, Tumor
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Culture Media, Conditioned
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Fibroblast Growth Factors / metabolism
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Gene Expression Profiling
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Humans
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MAP Kinase Signaling System
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Male
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Metalloproteins / biosynthesis*
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Metalloproteins / genetics
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Metalloproteins / pharmacology
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Mice
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Mice, Nude
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Multiple Myeloma / genetics
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Multiple Myeloma / metabolism*
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Multiple Myeloma / pathology
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Nuclear Proteins / biosynthesis*
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Nuclear Proteins / genetics
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Nuclear Proteins / pharmacology
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RNA-Binding Proteins / biosynthesis*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / pharmacology
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Receptor, Fibroblast Growth Factor, Type 3 / antagonists & inhibitors*
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Receptor, Fibroblast Growth Factor, Type 3 / biosynthesis
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Receptor, Fibroblast Growth Factor, Type 3 / genetics
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Ribosomal Proteins / biosynthesis*
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Ribosomal Proteins / genetics
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Ribosomal Proteins / pharmacology
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Signal Transduction
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Transfection
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Transplantation, Heterologous
Substances
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Culture Media, Conditioned
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Metalloproteins
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Nuclear Proteins
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RNA-Binding Proteins
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RPS27 protein, human
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Ribosomal Proteins
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Fibroblast Growth Factors
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Receptor, Fibroblast Growth Factor, Type 3