Abstract
The PRC2 histone methyltransferase complex is an important regulator of gene expression programs in metazoans. Gene expression regulation by the PRC2 complex is critical for development and cell differentiation. Several recent studies have begun to shed light on the molecular basis for the physiological function of the PRC2 complex. Here, we discuss some of these results and how they provide new insights into the composition, recruitment and regulation of the PRC2 complex.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation
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Cellular Reprogramming
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Chromatin / metabolism
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Enhancer of Zeste Homolog 2 Protein
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Gene Expression Regulation
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Histones / metabolism
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Humans
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Neoplasm Proteins
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Polycomb Repressive Complex 2 / chemistry
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Polycomb Repressive Complex 2 / metabolism*
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RNA, Untranslated / metabolism
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Retinoblastoma-Binding Protein 4 / metabolism
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Retinoblastoma-Binding Protein 7 / metabolism
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Stem Cells / cytology
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Stem Cells / metabolism
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Substrate Specificity
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Transcription Factors
Substances
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Chromatin
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EED protein, human
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Histones
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Neoplasm Proteins
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RNA, Untranslated
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Retinoblastoma-Binding Protein 4
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Retinoblastoma-Binding Protein 7
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SUZ12 protein, human
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Transcription Factors
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EZH1 protein, human
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EZH2 protein, human
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Enhancer of Zeste Homolog 2 Protein
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Polycomb Repressive Complex 2