Abstract
This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticholesteremic Agents / pharmacology*
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Brain / drug effects
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Brain / metabolism
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Humans
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Mice
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Neuroblastoma / pathology
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Oxidoreductases Acting on CH-CH Group Donors / genetics
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Oxidoreductases Acting on CH-CH Group Donors / metabolism*
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RNA, Messenger / metabolism
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Simvastatin / pharmacology*
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Time Factors
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Up-Regulation / drug effects*
Substances
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Anticholesteremic Agents
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Nerve Tissue Proteins
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RNA, Messenger
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Simvastatin
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Oxidoreductases Acting on CH-CH Group Donors
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DHCR24 protein, human