Nuclear architecture: the cell biology of a laminopathy

Curr Biol. 2011 Oct 11;21(19):R807-9. doi: 10.1016/j.cub.2011.09.006.

Abstract

Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / metabolism*
  • Humans
  • Laminin / metabolism*
  • Muscular Dystrophy, Emery-Dreifuss / genetics*
  • Point Mutation*

Substances

  • Caenorhabditis elegans Proteins
  • LMN-1 protein, C elegans
  • Laminin