Abstract
Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / metabolism*
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Caenorhabditis elegans Proteins / metabolism*
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Humans
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Laminin / metabolism*
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Muscular Dystrophy, Emery-Dreifuss / genetics*
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Point Mutation*
Substances
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Caenorhabditis elegans Proteins
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LMN-1 protein, C elegans
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Laminin