Abstract
Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Alleles
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Case-Control Studies
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Child
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Female
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Gene Dosage / genetics*
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Genetic Variation
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Humans
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Huntingtin Protein
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Huntington Disease / genetics*
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Male
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Models, Genetic*
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Nerve Tissue Proteins / genetics*
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Nuclear Proteins / genetics*
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Reference Values
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Selection, Genetic
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Trinucleotide Repeats*
Substances
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HTT protein, human
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Huntingtin Protein
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Nerve Tissue Proteins
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Nuclear Proteins