Abstract
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Brain Neoplasms / genetics
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Brain Neoplasms / mortality*
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Case-Control Studies
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DNA Repair / genetics*
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DNA-Binding Proteins / genetics*
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Denmark
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Female
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Genetic Predisposition to Disease
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Genotype
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Glioblastoma / genetics
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Glioblastoma / mortality*
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Humans
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Male
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Middle Aged
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MutS Homolog 2 Protein / genetics*
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Polymorphism, Single Nucleotide / genetics*
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Prognosis
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RecQ Helicases / genetics*
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Survival Rate
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Sweden
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United Kingdom
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Young Adult
Substances
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DNA-Binding Proteins
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RAD51B protein, human
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RECQL4 protein, human
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MSH2 protein, human
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MutS Homolog 2 Protein
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RecQ Helicases