Abstract
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anemia / chemically induced*
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Anemia / epidemiology
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Antiviral Agents / administration & dosage
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Antiviral Agents / adverse effects*
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Female
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HIV Infections / complications
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HIV Infections / drug therapy*
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / drug therapy*
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Humans
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Incidence
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Inosine Triphosphatase
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Male
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Middle Aged
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Polymorphism, Genetic*
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Pyrophosphatases / genetics*
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Pyrophosphatases / metabolism
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Ribavirin / administration & dosage
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Ribavirin / adverse effects*
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Risk Assessment
Substances
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Antiviral Agents
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Ribavirin
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Pyrophosphatases