Epidermal growth factor receptor mutations in small cell lung cancer patients who received surgical resection in China

Neoplasma. 2012;59(1):100-4. doi: 10.4149/neo_2012_013.

Abstract

To know the incidence of epidermal growth factor receptor (EGFR) mutations in small cell lung cancer (SCLC) patients who received surgical resection in mainland China. xTAG technology was used to detect the EGFR exon 19 and exon 21 mutations of 40 patients with SCLC who received surgical treatment in Zhejiang Cancer Hospital from 1998 to 2010. 2 of 40 cases were found with mutations in exon 19 of the EGFR gene. The mutation in exon 19 of the EGFR gene is in a female and non smoking patient which pathology is SCLC combined adenocarcinoma, and the other is male and smoking patient which pathology is SCLC combined squamous cell carcinoma. The EGFR mutation is rare in SCLC patients, and EGFR mutation might occur more often in combined SCLCs than conventional patients.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics
  • Adenocarcinoma / radiotherapy
  • Adenocarcinoma / secondary
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives
  • Carboplatin / administration & dosage
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / epidemiology
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / surgery
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / epidemiology
  • Carcinoma, Small Cell / genetics*
  • Carcinoma, Small Cell / radiotherapy
  • Carcinoma, Small Cell / secondary
  • Carcinoma, Small Cell / surgery
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / surgery
  • China / epidemiology
  • Combined Modality Therapy
  • Cranial Irradiation
  • Docetaxel
  • Endostatins / administration & dosage
  • Exons / genetics
  • Female
  • Genes, erbB-1*
  • Humans
  • Incidental Findings
  • Irinotecan
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Mutation*
  • Neoplasms, Multiple Primary / drug therapy
  • Neoplasms, Multiple Primary / epidemiology
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / surgery
  • Pneumonectomy
  • Recombinant Proteins
  • Smoking / genetics
  • Taxoids / administration & dosage
  • Young Adult

Substances

  • Endostatins
  • Recombinant Proteins
  • Taxoids
  • Docetaxel
  • Irinotecan
  • Carboplatin
  • endostar protein
  • Camptothecin