Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population

Rita Nemr; Ahmad W Almawi; Akram Echtay; Mai S Sater; Hoda S Daher; Wassim Y Almawi

doi:10.1016/j.diabres.2011.11.002

Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population

Diabetes Res Clin Pract. 2012 Feb;95(2):e37-40. doi: 10.1016/j.diabres.2011.11.002. Epub 2011 Nov 26.

Authors

Rita Nemr¹, Ahmad W Almawi, Akram Echtay, Mai S Sater, Hoda S Daher, Wassim Y Almawi

Affiliation

¹ University Medical Center Rizk Hospital, Beirut, Lebanon.

PMID: 22119613
DOI: 10.1016/j.diabres.2011.11.002

Abstract

We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.

MeSH terms

Arabs / genetics*
Cyclin-Dependent Kinase 5 / genetics*
Cyclin-Dependent Kinase Inhibitor p15 / genetics*
Cyclin-Dependent Kinase Inhibitor p16 / genetics*
Diabetes Mellitus, Type 2 / genetics*
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lebanon / epidemiology
Polymorphism, Single Nucleotide
Transcription Factors
tRNA Methyltransferases

Substances

CDKN2B protein, human
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Transcription Factors
tRNA Methyltransferases
Cyclin-Dependent Kinase 5
CDKAL1 protein, human