Abstract
This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.
MeSH terms
-
Administration, Oral
-
Adolescent
-
Angiography, Digital Subtraction
-
Antibodies, Antiphospholipid / blood
-
Anticoagulants / administration & dosage
-
Antiphospholipid Syndrome / blood
-
Antiphospholipid Syndrome / complications*
-
Antiphospholipid Syndrome / diagnosis
-
Antiphospholipid Syndrome / genetics
-
Antiphospholipid Syndrome / immunology
-
Arterial Occlusive Diseases / blood
-
Arterial Occlusive Diseases / diagnosis
-
Arterial Occlusive Diseases / drug therapy
-
Arterial Occlusive Diseases / etiology*
-
Biomarkers / blood
-
Constriction, Pathologic
-
Female
-
Fibrinolytic Agents / therapeutic use
-
Genetic Predisposition to Disease
-
Heredity
-
Humans
-
Ischemia / etiology
-
Pedigree
-
Popliteal Artery* / diagnostic imaging
-
Radial Artery* / diagnostic imaging
-
Thrombolytic Therapy
-
Tissue Plasminogen Activator / therapeutic use
-
Treatment Outcome
-
Warfarin / administration & dosage
Substances
-
Antibodies, Antiphospholipid
-
Anticoagulants
-
Biomarkers
-
Fibrinolytic Agents
-
Warfarin
-
Tissue Plasminogen Activator
Supplementary concepts
-
Familial antiphospholipid syndrome