TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms

Ann N Y Acad Sci. 2011 Dec:1245:36-7. doi: 10.1111/j.1749-6632.2011.06326.x.

Abstract

Transient receptor potential (TRP) receptors are ion channels that mediate pain and inflammation. We provide evidence for the distinct roles of TRPV1 and TRPA1 in arthritis.

MeSH terms

  • Animals
  • Arthritis, Experimental / etiology
  • Arthritis, Experimental / physiopathology
  • Disease Models, Animal
  • Freund's Adjuvant / toxicity
  • Humans
  • Inflammation / physiopathology*
  • Mice
  • Mice, Knockout
  • Pain / physiopathology*
  • TRPA1 Cation Channel
  • TRPV Cation Channels / deficiency
  • TRPV Cation Channels / genetics
  • TRPV Cation Channels / physiology*
  • Transient Receptor Potential Channels / deficiency
  • Transient Receptor Potential Channels / genetics
  • Transient Receptor Potential Channels / physiology*

Substances

  • TRPA1 Cation Channel
  • TRPV Cation Channels
  • TRPV1 protein, mouse
  • Transient Receptor Potential Channels
  • Trpa1 protein, mouse
  • Freund's Adjuvant