Cefixime-induced oculogyric crisis

Pediatr Emerg Care. 2012 Jan;28(1):55-6. doi: 10.1097/PEC.0b013e31823f252d.

Abstract

Oculogyric crisis is a neurologic adverse event characterized by bilateral dystonic, usually upward, conjugate eye deviations. Cefixime is a third-generation cephalosporin and is widely used in clinical practice in childhood. Confusion, encephalopathy, coma, myoclonus, nonconvulsive status epilepticus, and seizures have been described with the use of cephalosporins. We presented a cefixime-induced oculogyric crisis in a 7-year-old boy during the treatment of urinary tract infection, and this is the first case of cefixime-induced oculogyric crisis whose ocular symptoms gradually disappeared within 48 hours after the drug was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / complications
  • Cefixime / adverse effects*
  • Cefixime / pharmacology
  • Cefixime / therapeutic use
  • Child
  • Dopamine Antagonists / adverse effects
  • Dopamine Antagonists / pharmacology
  • GABA Antagonists / adverse effects
  • GABA Antagonists / pharmacology
  • Humans
  • Male
  • Neurologic Examination
  • Ocular Motility Disorders / chemically induced*
  • Ocular Motility Disorders / complications
  • Ocular Motility Disorders / physiopathology
  • Postoperative Complications / drug therapy
  • Recurrence
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy
  • Urinary Tract Infections / complications
  • Urinary Tract Infections / drug therapy

Substances

  • Anti-Bacterial Agents
  • Dopamine Antagonists
  • GABA Antagonists
  • Cefixime