Abstract
Oculogyric crisis is a neurologic adverse event characterized by bilateral dystonic, usually upward, conjugate eye deviations. Cefixime is a third-generation cephalosporin and is widely used in clinical practice in childhood. Confusion, encephalopathy, coma, myoclonus, nonconvulsive status epilepticus, and seizures have been described with the use of cephalosporins. We presented a cefixime-induced oculogyric crisis in a 7-year-old boy during the treatment of urinary tract infection, and this is the first case of cefixime-induced oculogyric crisis whose ocular symptoms gradually disappeared within 48 hours after the drug was discontinued.
MeSH terms
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Attention Deficit Disorder with Hyperactivity / complications
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Cefixime / adverse effects*
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Cefixime / pharmacology
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Cefixime / therapeutic use
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Child
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Dopamine Antagonists / adverse effects
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Dopamine Antagonists / pharmacology
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GABA Antagonists / adverse effects
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GABA Antagonists / pharmacology
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Humans
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Male
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Neurologic Examination
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Ocular Motility Disorders / chemically induced*
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Ocular Motility Disorders / complications
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Ocular Motility Disorders / physiopathology
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Postoperative Complications / drug therapy
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Recurrence
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Staphylococcal Infections / complications
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Staphylococcal Infections / drug therapy
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Urinary Tract Infections / complications
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Urinary Tract Infections / drug therapy
Substances
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Anti-Bacterial Agents
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Dopamine Antagonists
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GABA Antagonists
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Cefixime