Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression

Neuropsychobiology. 2012;65(2):70-5. doi: 10.1159/000329553. Epub 2012 Jan 5.

Abstract

In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents / therapeutic use
  • Depressive Disorder, Major / drug therapy
  • Depressive Disorder, Major / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genotype
  • Heterotrimeric GTP-Binding Proteins / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Receptors, Kainic Acid / genetics*
  • Regression Analysis
  • Treatment Outcome

Substances

  • Antidepressive Agents
  • G-protein beta3 subunit
  • GRIK4 protein, human
  • Receptors, Kainic Acid
  • Heterotrimeric GTP-Binding Proteins