Nurr1 haplotypes are associated with femoropopliteal restenosis/re-occlusion after percutaneous transluminal angioplasty

Eur J Vasc Endovasc Surg. 2012 Mar;43(3):337-8. doi: 10.1016/j.ejvs.2011.12.002. Epub 2012 Jan 9.

Abstract

Restenosis/re-occlusion remains a frequent complication in the first year after percutaneous transluminal angioplasty (PTA). In this study, association of nuclear receptor related 1 protein (Nurr1) haplotypes to the restenosis/re-occlusion rate after femoropopliteal PTA was investigated. Patients (n = 142) with disabling claudication or critical limb ischaemia, who had undergone technically successful femoropopliteal PTA, were prospectively followed up by vascular ultrasound imaging 12 months after the procedure. Nurr1 haplotypes 2 and 3 were associated significantly with the restenosis/re-occlusion rate (adjusted odds ratio 1.6, 95% confidence interval (CI) 1.1-2.3 and 2.0, 1.3-2.8, respectively) on univariate analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty / adverse effects*
  • Arterial Occlusive Diseases / diagnostic imaging
  • Arterial Occlusive Diseases / genetics*
  • Arterial Occlusive Diseases / therapy*
  • Female
  • Femoral Artery / diagnostic imaging*
  • Haplotypes / genetics*
  • Humans
  • Male
  • Nuclear Receptor Subfamily 4, Group A, Member 2 / genetics*
  • Polymorphism, Genetic
  • Popliteal Artery / diagnostic imaging*
  • Recurrence
  • Risk Factors
  • Ultrasonography

Substances

  • NR4A2 protein, human
  • Nuclear Receptor Subfamily 4, Group A, Member 2