RETRACTED: Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells

Cancer Lett. 2012 Jun 28;319(2):173-181. doi: 10.1016/j.canlet.2012.01.013. Epub 2012 Jan 17.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor in Chief. An investigation by Wayne State University identified a discrepancy between the data reported in Figures 1 A and 3 and the original collected data. The investigation committee concluded that this undermined the scientific basis of the publication, that no credible replacement data were available, and advised that the publication should be retracted.

Publication types

  • Research Support, N.I.H., Extramural
  • Retracted Publication

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Curcumin / analogs & derivatives*
  • Curcumin / pharmacology
  • Down-Regulation / drug effects
  • Female
  • GTP Phosphohydrolases / metabolism*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Genes, ras
  • Humans
  • Mice
  • Mice, SCID
  • MicroRNAs / physiology*
  • Pancreatic Neoplasms / genetics*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins p21(ras)
  • Transfection
  • ras Proteins / genetics
  • ras Proteins / metabolism*

Substances

  • Antineoplastic Agents
  • KRAS protein, human
  • MIRN143 microRNA, human
  • MIRN21 microRNA, human
  • MicroRNAs
  • Proto-Oncogene Proteins
  • mirnlet7 microRNA, human
  • GTP Phosphohydrolases
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins
  • Curcumin