Abstract
We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I(249)T(280) haplotype was significantly lower in SP compared to RR patients (RR>10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01; OR=0.53, 95%CI=0.18-1.56, p=0.2, in SP<10 years vs. RR>10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I₂₄₉T₂₈₀ haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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CX3C Chemokine Receptor 1
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Female
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Genetic Predisposition to Disease / epidemiology
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Genetic Predisposition to Disease / genetics*
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Haplotypes / genetics*
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Humans
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Isoleucine / genetics
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Male
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Methionine / genetics
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Middle Aged
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Multiple Sclerosis, Chronic Progressive / epidemiology
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Multiple Sclerosis, Chronic Progressive / genetics*
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Multiple Sclerosis, Chronic Progressive / immunology
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Multiple Sclerosis, Relapsing-Remitting / epidemiology
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Multiple Sclerosis, Relapsing-Remitting / genetics*
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Multiple Sclerosis, Relapsing-Remitting / immunology
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Polymorphism, Genetic / genetics
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Receptors, Chemokine / genetics*
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Threonine / genetics
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Valine / genetics
Substances
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CX3C Chemokine Receptor 1
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CX3CR1 protein, human
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Receptors, Chemokine
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Isoleucine
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Threonine
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Methionine
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Valine